Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 79.00 | |
25 mg | In stock | $ 118.00 | |
50 mg | In stock | $ 169.00 | |
100 mg | In stock | $ 297.00 | |
200 mg | In stock | $ 455.00 | |
500 mg | In stock | $ 736.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury. |
Targets&IC50 | HBV(in HepG2 cell):3.75 nM(ec50) |
In vitro | BMS-200475 has a EC50 of 3.75 nM against HBV that is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2]. |
In vivo | Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months is effective in reducing the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3]. |
Cell Research | BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1]. |
Synonyms | BMS200475, SQ34676 |
Molecular Weight | 277.28 |
Formula | C12H15N5O3 |
CAS No. | 142217-69-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (198.36 mM)
You can also refer to dose conversion for different animals. More
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Entecavir 142217-69-4 Microbiology/Virology HBV BMS200475 BMS-200475 Hepatitis B virus SQ34676 SQ 34676 SQ-34676 BMS 200475 inhibit Inhibitor inhibitor