Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 513.00 | |
5 mg | In stock | $ 997.00 | |
10 mg | In stock | $ 1,330.00 | |
25 mg | In stock | $ 1,990.00 | |
50 mg | In stock | $ 2,690.00 | |
100 mg | In stock | $ 3,620.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 997.00 |
Description | Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells. |
In vitro | In this study, we demonstrated that Eriocalyxin B was efficacious in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Treatment with Eriocalyxin B led to amelioration of EAE, which correlated with reduced spinal cord inflammation and demyelination. Eriocalyxin B treatment abolished encephalitogenic T-cell responses to myelin oligodendrocyte glycoprotein in an adoptive transfer EAE model. The underlying mechanism of Eriocalyxin B-induced effects involved inhibition of T helper (Th) 1 and Th17 cell differentiation through Janus Kinase/Signal Transducer and Activator Of Transcription and Nuclear factor-κB signaling pathways as well as elevation of reactive oxygen species[1] |
Source |
Molecular Weight | 344.4 |
Formula | C20H24O5 |
CAS No. | 84745-95-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (159.7 mM)
You can also refer to dose conversion for different animals. More
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Eriocalyxin B 84745-95-9 Apoptosis GPCR/G Protein JAK/STAT signaling NF-Κb Stem Cells NF-κB STAT cAMP inhibit Inhibitor inhibitor