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Eslicarbazepine

Catalog No. T3285L CAS 104746-04-5

Synonyms: Pazzul, Stedesa, Erelib, BIA 2-194, EC 810-248-9

Eslicarbazepine can be used for adjunctive therapy for adults with partial-onset seizures.

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Eslicarbazepine, CAS 104746-04-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eslicarbazepine can be used for adjunctive therapy for adults with partial-onset seizures.
In vitro	Eslicarbazepine is an anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. Eslicarbazepine acetate is a prodrug for eslicarbazepine (S-licarbazepine), which is a dual Inhibitor of β-Secretase and voltage-gated sodium channel[1][2].

Synonyms	Pazzul, Stedesa, Erelib, BIA 2-194, EC 810-248-9
Molecular Weight	254.28
Formula	C15H14N2O2
CAS No.	104746-04-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 12 mg/mL (47.19 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Doeser A, Soares-da-Silva P, Beck H, Uebachs M. The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits. Epilepsy Res. 2014 Feb;108(2):202-11. doi: 10.1016/j.eplepsyres.2013.11.022. Epub 2013 Dec 8. PubMed PMID: 24368131. 2. Keating GM. Eslicarbazepine acetate: a review of its use as adjunctive therapy in refractory partial-onset seizures. CNS Drugs. 2014 Jul;28(7):583-600. doi: 10.1007/s40263-014-0182-2. Review. PubMed PMID: 24972948. 3. Verrotti A, Loiacono G, Rossi A, Zaccara G. Eslicarbazepine acetate: an update on efficacy and safety in epilepsy. Epilepsy Res. 2014 Jan;108(1):1-10. doi: 10.1016/j.eplepsyres.2013.10.005. Epub 2013 Oct 23. Review. PubMed PMID: 24225327. 4. Elger C, Bialer M, Falcão A, Vaz-da-Silva M, Nunes T, Almeida L, Soares-da-Silva P. Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers. Epilepsia. 2013 Aug;54(8):1453-61. doi: 10.1111/epi.12242. Epub 2013 Jun 12. PubMed PMID: 23758485.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eslicarbazepine 104746-04-5 Membrane transporter/Ion channel Neuroscience Beta-Secretase Sodium Channel Pazzul Stedesa Inhibitor Erelib BIA 2-194 inhibit EC 810-248-9 inhibitor

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