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Evocarpine

Evocarpine
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
Catalog No. TN1121Cas No. 15266-38-3
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Purity:99.77%
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Evocarpine

Purity: 99.77%
Catalog No. TN1121Cas No. 15266-38-3

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$83In Stock
5 mg$197In Stock
10 mg$297In Stock
25 mg$516In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$228In Stock
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Product Introduction

Bioactivity
Description
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
In vitro
The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1]
Chemical Properties
Molecular Weight339.51
FormulaC23H33NO
Cas No.15266-38-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (147.27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9454 mL14.7271 mL29.4542 mL147.2711 mL
5 mM0.5891 mL2.9454 mL5.8908 mL29.4542 mL
10 mM0.2945 mL1.4727 mL2.9454 mL14.7271 mL
20 mM0.1473 mL0.7364 mL1.4727 mL7.3636 mL
50 mM0.0589 mL0.2945 mL0.5891 mL2.9454 mL
100 mM0.0295 mL0.1473 mL0.2945 mL1.4727 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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