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Fosifloxuridine nafalbenamide

Catalog No. T33762 CAS 1332837-31-6

Synonyms: NUC 3373, NUC3373, NUC-3373

NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.

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Fosifloxuridine nafalbenamide, CAS 1332837-31-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NUC 3373, NUC3373, NUC-3373
Molecular Weight	613.535
Formula	C29H29FN3O9P
CAS No.	1332837-31-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (162.99 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fiona G. McKissock, et al. Abstract 1848: NUC-3373 induces ER stress and the release of damage associated molecular patterns in colorectal cancer cells. Cancer Res August 15 2020 (80) (16 Supplement) 1848.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fosifloxuridine nafalbenamide 1332837-31-6 DNA损伤和修复细胞周期 DNA/RNA Synthesis inhibit anti-cancer FdUMP 5-FU 5-fluorouracil fluorodeoxyuridine FUDR 5-fluorodeoxyuridine NUC-3373 NUC 3373 monophosphate Inhibitor Thymidylate Synthase NUC3373 inhibitor

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