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Metabolism ROR GSK2981278

GSK2981278

Catalog No. T4050   CAS 1474110-21-8
Synonyms: ROR gama modulator 1
Purity 99.78% Datasheet MSDS

GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).

GSK2981278, CAS 1474110-21-8
Pack Size Availability Price/USD Quantity
1 mg In stock 70.00
5 mg In stock 110.00
10 mg In stock 160.00
25 mg In stock 288.00
50 mg In stock 490.00
100 mg In stock 770.00
1 mL * 10 mM (in DMSO) In stock 110.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
Targets&IC50 RORγ,  
Synonyms ROR gama modulator 1
Purity 99.52%
Molecular Weight 461.61
Formula C25H35NO5S
CAS No. 1474110-21-8

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Birault Veronique, et al. Preparation of tetrahydropyranylmethoxy benzenesulfonamide compounds as RORγ modulators useful in therapy of various diseases. From PCT Int. Appl. (2015), WO 2015061515 A1 20150430. 2. Birault Veronique, et al. Preparation of tertiary N-arylbenzenesulfonamides as RORγ modulators useful in treatment of inflammatory, metabolic, and autoimmune diseases. From PCT Int. Appl. (2013), WO 2013160418 A1 20131031. 3. Smith SH, et al. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PLoS One. 2016 Feb 12;11(2):e0147979.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets
TAK-828F Xylan Vimirogant AZD-0284 RORγt Inverse agonist 8 A-9758 S18-000003 FM26

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