GW791343 dihydrochloride

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

Catalog No. T7805Cas No. 1019779-04-4

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Purity:100%

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COA LCMS HNMR

GW791343 dihydrochloride

Catalog No. T7805Cas No. 1019779-04-4

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$68	In Stock
25 mg	$130	In Stock
50 mg	$226	In Stock
100 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
In vitro	GW791343 were non-competitive inhibitors of human P2X(7) receptors.?Receptor protection studies using decavanadate and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) showed that neither compound-17 nor GW791343 competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor.?GW791343 prevented the slowly reversible blockade of the human P2X(7) receptor produced by compound-17 and inhibited [(3)H]-compound-17 binding to the P2X(7) receptor suggesting they may bind to similar or interacting sites[1].
Alias	GW791343 (HCl)

Chemical Properties

Molecular Weight	447.35
Formula	C₂₀H₂₆Cl₂F₂N₄O
Cas No.	1019779-04-4

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 42 mg/mL (93.89 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2354 mL	11.1769 mL	22.3539 mL	111.7693 mL
5 mM	0.4471 mL	2.2354 mL	4.4708 mL	22.3539 mL
10 mM	0.2235 mL	1.1177 mL	2.2354 mL	11.1769 mL
20 mM	0.1118 mL	0.5588 mL	1.1177 mL	5.5885 mL
50 mM	0.0447 mL	0.2235 mL	0.4471 mL	2.2354 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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