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Gatifloxacin hydrochloride

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Catalog No. T8384Cas No. 121577-32-0
Alias PD135432 (hydrochloride), BMS-206584 (hydrochloride), AM-1155 (hydrochloride)

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.

Gatifloxacin hydrochloride

Gatifloxacin hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T8384Alias PD135432 (hydrochloride), BMS-206584 (hydrochloride), AM-1155 (hydrochloride)Cas No. 121577-32-0
Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
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Purity:100%
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Product Introduction

Bioactivity
Description
Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
Targets&IC50
Topo II:36.7 μM
In vivo
All eyes showed evidence of infection by 48 hours postinoculation with 36 of 41 eyes (87.8%) exhibiting moderate-to-severe keratitis. All eyes exhibited corneal healing by day 15, with no significant differences among groups. Three of 4 groups receiving gatifloxacin tended to have smaller fluorescein retention area scores than did the ciprofloxacin group. No eyes tested positive for Pseudomonas at the end of the study. No corneal precipitates were found following as many as 48 doses/day of gatifloxacin[1].
Animal Research
Heptanol-induced corneal ulcers in New Zealand White rabbits (n = 41; 8 females/group) were inoculated with 10(6) CFU of Pseudomonas aeruginosa. Gatifloxacin 0.3% dosing varied among 4 groups with frequencies of 16-48 doses/day (days 1-2), 3-16 doses/day (days 3-7), and maintenance dosing of 3-4 doses/day (days 8-22). Ciprofloxacin 0.3% was administered as labeled for corneal ulcers, with 44 doses on day 1, 16 doses on day 2, and 4 doses/day on days 3-21[1]
AliasPD135432 (hydrochloride), BMS-206584 (hydrochloride), AM-1155 (hydrochloride)
Chemical Properties
Molecular Weight411.86
FormulaC19H23ClFN3O4
Cas No.121577-32-0
SmilesCl.COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mg/mL (24.28 mM), Sonication is recommended.
DMSO: 4.12 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.4280 mL12.1400 mL24.2801 mL121.4005 mL
5 mM0.4856 mL2.4280 mL4.8560 mL24.2801 mL
10 mM0.2428 mL1.2140 mL2.4280 mL12.1400 mL
H2O
1mg5mg10mg50mg
20 mM0.1214 mL0.6070 mL1.2140 mL6.0700 mL

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