conjunctivitis

Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.

Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.

Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.

Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).

Alcaftadine (Lastacaft) is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis.

Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. Lomefloxacin Hydrochloride is the hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.

Sulfacetamide (NSC-63871) is used to treat blepharitis or conjunctivitis (in eye-drop solution) by limiting the presence of folic acid which bacteria need to survive. sulfacetamide may serve as a treatment for mild forms of hidradenitis suppurativa. It is also used to control acne.

Human IgE Pentapeptide HEPP acetate is a pentapeptide that does not produce IgE inhibition in several different systems and is used in the treatment of conjunctivitis.

Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.

(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and conjunctivitis.

Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

Bepotastine (Bepotastine free base) free base is a histamine 1 (H1) receptor antagonis.

Olopatadine, an antihistamine, as well as anticholinergic and mast cell stabilizer, is used for the treatment of itching associated with allergic conjunctivitis (eye allergies). There is also a potential for Olopatadine to treat steroid rebound (red skin

Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.

Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.

Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.

Alcaftadine is a novel antihistamine for preventing allergic conjunctivitis.

Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Tripelennamine, an ethylenediamine derivative, acts as a potent histamine H1-receptor antagonist, effectively reducing the organism's allergic response to histamine. It is utilized in researching conditions such as rhinitis, conjunctivitis, and allergic and anaphylactic reactions [1] [2] [3].

Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.

Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

Chloropyramine is a competitive reversible H1 receptor antagonist that can be used in allergic conditions research, for example, conjunctivitis and bronchial asthma. Chloropyramine also shows anti-tumour activity in breast cancer [1] [2].

Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an H1-antagonist.

Tripelennamine citrate is an ethylenediamine derivative and is a potent histamine H1 receptor antagonist. tripelennamine citrate reduces histamine-induced allergic reactions in the body. tripelennamine citrate can be used to study rhinitis, conjunctivitis, allergic and anaphylactic reactions.

Ketorolac (RS37619) hemicalcium is a nonselective COX inhibitor with IC50 values of 20 nM for COX-1 and 120 nM for COX-2. This non-steroidal anti-inflammatory drug (NSAID) is used as a 0.5% ophthalmic solution for researching allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Additionally, it is a DDX3 inhibitor applicable in cancer research [1] [4].

Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis.

Bepotastine tosylate is a selective, orally active second-generation histamine H1 receptor antagonist that exhibits an inhibitory effect on histamine-mediated upregulation of nerve growth factor (NGF) expression. conjunctivitis and urticaria/pruritus.

Levocarbastine is a second-generation H1 receptor antagonist for allergic conjunctivitis. It also acts as a potent selective antagonist for the neurotensin receptor NTS2 and is the first drug to be used to characterize different neurotensin subtypes.

Pemirolast is an orally active antiallergic agent that attenuates paclitaxel hypersensitivity reactions by inhibiting the release of sensory neuropeptides, and can be used for bronchial asthma and conjunctivitis research [1] - [5].

Besifloxacin is the fourth generation of fluoroquinolones, which can be used to treat bacterial conjunctivitis

Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeabil

Chloramphenicol stearate is an antibiotic useful for the therapy of numbers of bacterial infections. This includes an eye ointment to treat conjunctivitis.

Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.