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Gemigliptin

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Catalog No. T7369Cas No. 911637-19-9
Alias LC15-0444

Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

Gemigliptin

Gemigliptin

🥰Excellent
Purity: 99.33%
Catalog No. T7369Alias LC15-0444Cas No. 911637-19-9
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$55In Stock
10 mg$89In Stock
25 mg$159In Stock
50 mg$272In Stock
100 mg$428In Stock
500 mg$969In Stock
1 mL x 10 mM (in DMSO)$81In Stock
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Purity:99.33%
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Product Introduction

Bioactivity
Description
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Targets&IC50
DPP4:7.25 nM(KD)
In vitro
Gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway[1].Gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells[2].
Cell Research
Using immunohistochemical and Western blot analysis, Quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins[2].
AliasLC15-0444
Chemical Properties
Molecular Weight489.36
FormulaC18H19F8N5O2
Cas No.911637-19-9
SmilesN[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCc2c(C1)nc(nc2C(F)(F)F)C(F)(F)F
Relative Density.1.54 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 122.5 mg/mL (250.33 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0435 mL10.2174 mL20.4349 mL102.1743 mL
5 mM0.4087 mL2.0435 mL4.0870 mL20.4349 mL
10 mM0.2043 mL1.0217 mL2.0435 mL10.2174 mL
20 mM0.1022 mL0.5109 mL1.0217 mL5.1087 mL
50 mM0.0409 mL0.2043 mL0.4087 mL2.0435 mL
100 mM0.0204 mL0.1022 mL0.2043 mL1.0217 mL

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