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Gemigliptin

Catalog No. T7369   CAS 911637-19-9
Synonyms: LC15-0444

Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

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Gemigliptin Chemical Structure
Gemigliptin, CAS 911637-19-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 34.00
5 mg In stock $ 55.00
10 mg In stock $ 89.00
25 mg In stock $ 159.00
50 mg In stock $ 272.00
100 mg In stock $ 428.00
500 mg In stock $ 969.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Targets&IC50 DPP-4:7.25 nM(KD)
In vitro Gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway[1].Gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells[2].
Cell Research Using immunohistochemical and Western blot analysis, Quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins[2].
Synonyms LC15-0444
Molecular Weight 489.36
Formula C18H19F8N5O2
CAS No. 911637-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 122.5 mg/mL (250.33 mM)

TargetMolReferences and Literature

1. Choi S Y , Ryu H M , Oh E J , et al. Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells[J]. PLoS ONE, 2017, 12(7):e0180393. 2. Jung, Beom, Seo, et al. Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.[J]. Diabetes & metabolism journal, 2019.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library ReFRAME Related Library Inhibitor Library Orally Active Compound Library Approved Drug Library Drug Repurposing Compound Library Protease Inhibitor Library Clinical Compound Library

Related Products

Related compounds with same targets
Anagliptin Retagliptin Phosphate Diprotin A Vildagliptin Evogliptin tartrate Sitagliptin phosphate monohydrate Gemigliptin Tartrate(911637-19-9 free base) Talabostat mesylate

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Keywords

Gemigliptin 911637-19-9 Proteases/Proteasome Ubiquitination Proteasome DPP-4 Inhibitor DPP Dipeptidyl Peptidase inhibit LC15-0444 inhibitor

 

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