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Glipizide

Catalog No. T1603 CAS 29094-61-9

Synonyms: CP 28720, K 4024

Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.

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Glipizide, CAS 29094-61-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 48.00
500 mg	In stock	$ 72.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.75%

Purity: 98.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Targets&IC50	KATP:6.4 nM ATP-sensitive potassium (IC50)
Kinase Assay	The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106?cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units.

Synonyms	CP 28720, K 4024
Molecular Weight	445.54
Formula	C21H27N5O4S
CAS No.	29094-61-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL (184 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Gribble FM, Ashcroft FM. Metabolism. 2000 Oct;49(10 Suppl 2):3-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Metabolism Disease Compound Library Pediatric Drug Library Drug-induced Liver Injury (DILI) Compound Library Anti-Obesity Compound Library Potassium Channel Blocker Library

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A2764 dihydrochloride Sematilide hydrochloride SCH-23390 hydrochloride Ecdysone NS6180 Paederosidic acid methyl ester Tolazamide RL648_81

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glipizide 29094-61-9 DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Potassium Channel PPAR ABC CP 28720 K 4024 type 2 diabetes sulfonylurea class K ATP KcsA Inhibitor mellitus CP-28720 inhibit K-4024 ATP-sensitive potassium CP28720 pancreatic β K4024 inhibitor

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