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GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 32 € | In Stock | |
2 mg | 44 € | In Stock | |
5 mg | 73 € | In Stock | |
10 mg | 115 € | In Stock | |
25 mg | 246 € | In Stock | |
50 mg | 491 € | In Stock | |
100 mg | 688 € | In Stock | |
200 mg | 908 € | In Stock | |
1 mL x 10 mM (in DMSO) | 80 € | In Stock |
Description | GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. |
Targets&IC50 | CFTR:4.3 μM(Ki) |
In vitro | GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3] |
In vivo | In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1] |
Alias | GlyH 101 |
Molecular Weight | 493.15 |
Formula | C19H15Br2N3O3 |
Cas No. | 328541-79-3 |
Smiles | OC1=C(Br)C(=O)\C(=C\NNC(=O)CNc2ccc3ccccc3c2)C=C1Br |
Relative Density. | 1.73 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 49.3 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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