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Harringtonine

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Purity:98.94%

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COA HNMR HPLC

Harringtonine

Catalog No. T8286Cas No. 26833-85-2

Harringtonine, a natural Cephalotaxus alkaloid, inhibits protein synthesis.

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Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$79	In Stock
10 mg	$119	In Stock
25 mg	$198	In Stock
50 mg	$296	In Stock
1 mL x 10 mM (in DMSO)	$92	In Stock

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Product Introduction

Bioactivity

Description

Harringtonine, a natural Cephalotaxus alkaloid, inhibits protein synthesis.

In vitro

Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation [1]. Harringtonine displays potent inhibition of Chikungunya virus infection (EC50: 0.24 μM). Harringtonine could inhibit other alphaviruses [2]. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations [3].

Chemical Properties

Molecular Weight	531.59
Formula	C28H37NO9
Cas No.	26833-85-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (103.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8811 mL	9.4057 mL	18.8115 mL	94.0575 mL
5 mM	0.3762 mL	1.8811 mL	3.7623 mL	18.8115 mL
10 mM	0.1881 mL	0.9406 mL	1.8811 mL	9.4057 mL
20 mM	0.0941 mL	0.4703 mL	0.9406 mL	4.7029 mL
50 mM	0.0376 mL	0.1881 mL	0.3762 mL	1.8811 mL
100 mM	0.0188 mL	0.0941 mL	0.1881 mL	0.9406 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc