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IPI-3063

Catalog No. T15592Cas No. 1425043-73-7

IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).

IPI-3063

IPI-3063

Purity: 99.08%
Catalog No. T15592Cas No. 1425043-73-7
IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
2 mg$58In Stock
5 mg$106In Stock
10 mg$178In Stock
25 mg$358In Stock
50 mg$497In Stock
100 mg$678In Stock
1 mL x 10 mM (in DMSO)$115In Stock
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Purity:99.08%
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Product Introduction

Bioactivity
Description
IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
Targets&IC50
p110γ:2187 nM, p110α:1170 nM, p110β:1508 nM, p110δ:2.5 nM
In vitro
IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very effective in reducing p-AKT (significant effect at 1?nM) and it also decreases p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very effective, achieving a significant decrease in B cell survival when present at 10?nM and it also inhibits p110α, p110β, and p110γ (IC50s: 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively). IPI-3063 effectively decreases mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1.
Chemical Properties
Molecular Weight455.51
FormulaC25H25N7O2
Cas No.1425043-73-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 83.33 mg/mL (182.94 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1953 mL10.9767 mL21.9534 mL109.7671 mL
5 mM0.4391 mL2.1953 mL4.3907 mL21.9534 mL
10 mM0.2195 mL1.0977 mL2.1953 mL10.9767 mL
20 mM0.1098 mL0.5488 mL1.0977 mL5.4884 mL
50 mM0.0439 mL0.2195 mL0.4391 mL2.1953 mL
100 mM0.0220 mL0.1098 mL0.2195 mL1.0977 mL

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