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IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $58 | In Stock | |
5 mg | $106 | In Stock | |
10 mg | $178 | In Stock | |
25 mg | $358 | In Stock | |
50 mg | $497 | In Stock | |
100 mg | $678 | In Stock | |
1 mL x 10 mM (in DMSO) | $115 | In Stock |
Description | IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM). |
Targets&IC50 | p110γ:2187 nM, p110α:1170 nM, p110β:1508 nM, p110δ:2.5 nM |
In vitro | IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very effective in reducing p-AKT (significant effect at 1?nM) and it also decreases p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very effective, achieving a significant decrease in B cell survival when present at 10?nM and it also inhibits p110α, p110β, and p110γ (IC50s: 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively). IPI-3063 effectively decreases mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1. |
Molecular Weight | 455.51 |
Formula | C25H25N7O2 |
Cas No. | 1425043-73-7 |
Smiles | CC(C)n1c(cc2cccc(-c3ccc(=O)n(C)c3)c2c1=O)[C@H](C)Nc1ncnc(N)c1C#N |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 83.33 mg/mL (182.94 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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