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Itanapraced

Catalog No. T2262 CAS 749269-83-8

Synonyms: CHF5074, CSP-1103

CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).

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Itanapraced, CAS 749269-83-8

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Purity: 98%

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Description	CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Targets&IC50	Aβ40:18.4 μM, Aβ42:3.6μM
Kinase Assay	GSK-3β activity assay: IC50 of new synthesised compound IM-12 to GSK-3β is determined by a luminometric GSK-3β activity assay. Briefly, compounds are tested in different concentrations diluted in assay buffer containing final concentrations of: 4 mM MOPS pH 7.2; 0.4 mM EDTA; 1 mM EGTA; 2.5 mM β-glycerophosphate; 4 mM MgCl2; 40 μM BSA; 0.05 mM DTT. Four microlitres of diluted compounds are added to 25 μM pGS-2 peptide substrate, 20 ng recombinant GSK-3β and 1 μM ATP to a total assay volume of 40 μl. The enzymatic reaction is stopped after 30 min of incubation at 30 °C by adding 40 μl KinaseGlo. The luminometric signal is allowed to stabilise for 10 min and the measured with a Glomax? 96 Microplate Luminometer.

Synonyms	CHF5074, CSP-1103
Molecular Weight	325.16
Formula	C16H11Cl2FO2
CAS No.	749269-83-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 37 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Anti-Parkinson's Disease Compound Library Inhibitor Library Anti-Alzheimer's Disease Compound Library Drug Repurposing Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

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Keywords

Itanapraced 749269-83-8 蛋白酶体干细胞神经科学 Beta Amyloid Gamma-secretase CHF5074 Inhibitor CSP 1103 CHF-5074 Gamma secretase γ-secretase CHF 5074 CSP-1103 CSP1103 inhibit inhibitor

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