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K-604 dihydrochloride

Catalog No. T11733Cas No. 217094-32-1

K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.

K-604 dihydrochloride

K-604 dihydrochloride

Purity: 99.34%
Catalog No. T11733Cas No. 217094-32-1
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
2 mg$74In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$397In Stock
50 mg$589In Stock
100 mg$843In Stock
1 mL x 10 mM (in DMSO)$169In Stock
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Purity:99.34%
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Product Introduction

Bioactivity
Description
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
Targets&IC50
ACAT1:0.45 μM, ACAT2:102.85 μM
In vitro
a novel ACAT inhibitor, K-604. The IC(50) values of K-604 for human ACAT-1 and ACAT-2 were 0.45 and 102.85 micromol/L, respectively, indicating that K-604 is 229-fold more selective for ACAT-1. Kinetic analysis indicated that the inhibition was competitive with respect to oleoyl-coenzyme A with a K(i) value of 0.378 micromol/L. Exposure of human monocyte-derived macrophages to K-604 inhibited cholesterol esterification with IC(50) of 68.0 nmol/L. Furthermore, cholesterol efflux from THP-1 macrophages to HDL(3) or apolipoprotein A-I was enhanced by K-604[1].
Chemical Properties
Molecular Weight575.64
FormulaC23H32Cl2N6OS3
Cas No.217094-32-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 62.5 mg/mL (108.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7372 mL8.6860 mL17.3720 mL86.8598 mL
5 mM0.3474 mL1.7372 mL3.4744 mL17.3720 mL
10 mM0.1737 mL0.8686 mL1.7372 mL8.6860 mL
20 mM0.0869 mL0.4343 mL0.8686 mL4.3430 mL
50 mM0.0347 mL0.1737 mL0.3474 mL1.7372 mL
100 mM0.0174 mL0.0869 mL0.1737 mL0.8686 mL

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