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K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor 12
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Purity:99.44%
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K-Ras(G12C) inhibitor 12

Catalog No. T6555Cas No. 1469337-95-8
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
5 mg$96In Stock
10 mg$145In Stock
25 mg$263In Stock
50 mg$396In Stock
100 mg$596In Stock
1 mL x 10 mM (in DMSO)$105In Stock
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Product Introduction

Bioactivity
Description
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.
In vitro
K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]
Chemical Properties
Molecular Weight449.67
FormulaC15H17ClIN3O3
Cas No.1469337-95-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 26 mg/mL (57.8 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2239 mL11.1193 mL22.2385 mL111.1927 mL
5 mM0.4448 mL2.2239 mL4.4477 mL22.2385 mL
10 mM0.2224 mL1.1119 mL2.2239 mL11.1193 mL
20 mM0.1112 mL0.5560 mL1.1119 mL5.5596 mL
50 mM0.0445 mL0.2224 mL0.4448 mL2.2239 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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