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K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $33 | In Stock | |
5 mg | $52 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $165 | In Stock | |
50 mg | $289 | In Stock | |
100 mg | $428 | In Stock | |
1 mL x 10 mM (in DMSO) | $58 | In Stock |
Description | K 02288 is a novel small molecule inhibitor of ALK1/2/3/6. |
Targets&IC50 | ALK2:1.1 nM, ALK1:1.8 nM, ALK6:6.4 nM, ALK3:34.4 nM |
In vitro | In zebrafish embryos, K02288 induces dorsal phenotypes in a dose-dependent manner without affecting the formation of intersegmental vessels (ISV). |
In vivo | K02288 dose-dependently inhibits Smad1/5/8 phosphorylation induced by BMP4 and BMP6 in C2C12 cells without affecting TGF-β-BMP signaling. |
Alias | K 02288 |
Molecular Weight | 352.38 |
Formula | C20H20N2O4 |
Cas No. | 1431985-92-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3.5 mg/mL (10 mM)), Heating is recommended. DMSO: 50 mg/mL (141.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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