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Karanjin

Catalog No. T2S0820   CAS 521-88-0

Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.

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Karanjin Chemical Structure
Karanjin, CAS 521-88-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 43.00
5 mg In stock $ 98.00
10 mg In stock $ 172.00
25 mg In stock $ 288.00
50 mg In stock $ 433.00
100 mg In stock $ 628.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.
In vitro Karanjin is a furanoflavonol, insecticidal and acaricidal activities.?The present study was intended to evaluate the biochemical interactions of karanjin with bovine serum albumin (BSA) and study its toxicological effects on mammalian and bacterial cell lines.?Karanjin bound to BSA at a single site with a dissociation constant of 19.7 μM.?Evaluation of BSA-karanjin interactions at three different temperatures indicated the involvement of static mode of quenching.?Binding experiments in the presence of warfarin and computational docking analysis indicated that karanjin bound closer to the warfarin binding site located in the Subdomain IIA of BSA.?Using F?rster resonance energy transfer analysis the distance between TRP 213 of BSA and karanjin was found to be 20 ?.?Collective results from synchronous fluorescence spectra analysis, differential scanning calorimetry, and circular dichroism analysis indicated that binding of karanjin induced conformational changes in the secondary structure of BSA.?Karanjin exhibited low toxicity against human cervical cancer cells and normal mouse fibroblast L929 cells and modestly inhibited the growth of B. subtilis and E. coli cells[3].
Source
Molecular Weight 292.29
Formula C18H12O4
CAS No. 521-88-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.92 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

3. Raghav D , Mahanty S , Rathinasamy K . Biochemical and toxicological investigation of karanjin, a bio-pesticide isolated from Pongamia seed oil - ScienceDirect[J]. Pesticide Biochemistry and Physiology, 2019, 157:108-121.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Breast Cancer Compound Library Anti-Obesity Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library Stem Cell Differentiation Compound Library Anti-Colorectal Cancer Compound Library Chinese Pharmacopoeia Natural Product Library Antioxidant Compound Library

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Piclidenoson Linifanib Geranylgeraniol Dextran sulfate sodium salt (MW 4500-5500) 4-Thiothymidine Beta-Sitosterol PNU-74654 PF-3758309 hydrochloride

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Keywords

Karanjin 521-88-0 Apoptosis Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK AMP-activated protein kinase muscle death GLUT4 cell inhibit Inhibitor translocation skeletal inhibitor

 

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