Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
2 mg | In stock | $ 223.00 | |
5 mg | In stock | $ 345.00 | |
10 mg | In stock | $ 547.00 | |
25 mg | In stock | $ 886.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,630.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | LY2562175 is an effective and selective FXR agonist (EC50: 193 nM). |
Targets&IC50 | FXR:(EC50)193 nM |
In vitro | LY2562175 boosts transcriptional activation of human FXR in a cell-based co-transfection assay (EC50: 193 nM) and it also promotes the recruitment of a peptide from the nuclear receptor interaction domain of the coactivator SRC-1 (a relative EC50: 121 nM). It has 93.5% efficacy as compare to GW4064. |
In vivo | LY2562175 induces a dose-dependent decrease in serum cholesterol and serum triglycerides. LY2562175(female ZDF rats) treatment, causes a dose-dependent lowering of plasma triglycerides in the fasted and nonfasted states. LY2562175 further lowers fasted and nonfasted plasma triglycerides when administered as a fixed-dose combination with BRL49653. At a dose of 10 mg/kg, the decrease in cholesterol with LY2562175 is 80% below vehicle-treated animals, and the decrease in serum triglycerides is 76% from the control group. The ED50 for serum cholesterol is determined to be 2 and 3.4 mg/kg for serum triglycerides. FPLC fractionation of the lipoproteins shows that LY2562175 treatment causes a reduction in vLDL-C and a dramatic increase in HDL-c in this animal model. |
Molecular Weight | 540.44 |
Formula | C28H27Cl2N3O4 |
CAS No. | 1103500-20-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 62.5 mg/mL (115.65 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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LY2562175 1103500-20-4 Autophagy Metabolism FXR NR1H4 Inhibitor LY 2562175 inhibit LY-2562175 inhibitor