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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $120 | In Stock | |
5 mg | $290 | In Stock | |
10 mg | $440 | In Stock | |
25 mg | $728 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,390 | In Stock | |
500 mg | $2,770 | In Stock | |
1 mL x 10 mM (in DMSO) | $277 | In Stock |
Description | Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease. |
Targets&IC50 | AChE:31.8 μM, MAO-B:37.1 μM |
In vitro | Ladostigil (1-10 µM) demonstrates neuroprotective effects by preventing the decline in mitochondrial membrane potential (ψ), reducing apoptotic cascades, and inhibiting the production of reactive oxygen species (ROS) induced by OS insults.[6] Ladostigil (1-10 µM) exhibits notable neuroprotective effects in human neuroblastoma SK-N-SH cells. These effects involve the inhibition of caspase-3 activation, upregulation of Bcl-2 expression, and downregulation of Bad and Bax gene and protein expression.[6] |
In vivo | Ladostigil (17 mg/kg; p.o. daily for 6 weeks) eliminates hyperanxiety and depressive-like behavior in adult rats exposed to prenatal stress, as shown in the elevated plus maze (EPM) and forced swim tests (FST).[8] Ladostigil (50 μmol/kg; single p.o.) also restores episodic memory in the object recognition test in rats.[7] |
Alias | TV-3326, Ladostigil, TV 3326, TV3326, Ladostigil free base |
Molecular Weight | 272.34 |
Formula | C16H20N2O2 |
Cas No. | 209394-27-4 |
Storage | |||||||||||||||||||||
Solubility Information | DMSO: 4.8 mg/mL (17.63 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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