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MK-3697

Catalog No. T1913 CAS 1224846-01-8

MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).

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MK-3697, CAS 1224846-01-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 63.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 98.4%

Purity: 98.15%

Biological Description

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Storage & Solubility Information

Description	MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
Targets&IC50	OX2:0.95 nM(ki)
Kinase Assay	Cyclin/CDK kinase assay: Recombinant cyclin/CDK holoenzymes are purified from Sf9 cells engineered to produce baculoviruses that express a specific cyclin or CDK. Cyclin/CDK complexes are typically diluted to a final concentration of 50 μg/mL in a kinase reaction buffer containing 50 mM Tris-HCl (pH 8.0), 10 mM MgCl2, 1 mM DTT, and 0.1 mM sodium orthovanadate. For each kinase reaction, 1 μg of enzyme and 20 μL of a 2-μM substrate solution (a biotinylated peptide derived from histone H1) are mixed and combined with 10 μL of diluted Dinaciclib. The reaction is started by the addition of 50 μL of 2 μM ATP and 0.1 μCi of 33P-ATP. Kinase reactions are incubated for 1 hour at room temperature and are stopped by the addition of 0.1% Triton X-100, 1 mM ATP, 5 mM EDTA, and 5 mg/mL streptavidin-coated SPA beads. SPA beads are captured using a 96-well GF/B filter plate and a Filtermate universal harvester. Beads are washed twice with 2 M NaCl and twice with 2 M NaCl containing 1% phosphoric acid. The signal is then assayed using a TopCount 96-well liquid scintillation counter.

Molecular Weight	447.51
Formula	C23H21N5O3S
CAS No.	1224846-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (122.9 mM)

References and Literature

1. Anthony J. Roecker, et al. Bioorganic & Medicinal Chemistry Letters Available online 26 August 2014.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-COVID-19 Compound Library Bioactive Compound Library ReFRAME Related Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-3697 1224846-01-8 GPCR/G Protein Neuroscience OX Receptor Inhibitor Hypocretin Receptor MK 3697 inhibit Orexin Receptor (OX Receptor) HCRT Receptor MK3697 inhibitor

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