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ML251

Catalog No. T64320   CAS 1486482-16-9

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ML251 Chemical Structure
ML251, CAS 1486482-16-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
500 mg In stock $ 2,860.00
1 mL * 10 mM (in DMSO) In stock $ 317.00
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Purity: 99.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Targets&IC50 T. brucei PFK:0.37 μM, T. cruzi PFK:0.13 μM
In vitro ML251 produces modest dose-dependent toxicity[1].
Cell Research The cell cytotoxicity assay of ML251 (0~33.3 μg/mL) in T. brucei cell shows dose-dependent reduction of cell viability[1].
Molecular Weight 426.27
Formula C17H13Cl2N3O4S
CAS No. 1486482-16-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 249 mg/mL (584.13 mM), sonification is recommended.

TargetMolReferences and Literature

1. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Glycolysis Compound Library Bioactive Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Metabolism Compound Library NO PAINS Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Inhibitor Library

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Keywords

ML251 1486482-16-9 Metabolism Microbiology/Virology Glucokinase Parasite cruzi inhibit ML 251 brucei MRC-5 Inhibitor nanomolar ML-251 inhibitor

 

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