store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 33.00 | |
10 mg | In stock | $ 46.00 | |
25 mg | In stock | $ 75.00 | |
50 mg | In stock | $ 109.00 | |
100 mg | In stock | $ 163.00 | |
200 mg | In stock | $ 243.00 | |
500 mg | In stock | $ 397.00 | |
1 g | In stock | $ 588.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells. |
In vitro | SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD. MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.[1]. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3]. |
Molecular Weight | 297.13 |
Formula | C12H12IN |
CAS No. | 36913-39-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (336.54 mM), Sonification is recommended.
DMSO: 62.5 mg/mL (210.34 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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MPP+ iodide 36913-39-0 Autophagy Metabolism Mitochondrial Metabolism MPP+ dopaminergic neurons respiratory chain Inhibitor inhibit neurotoxic MPP+ Iodide complex inhibitor