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Mizolastine

Catalog No. T0118 CAS 108612-45-9

Synonyms: SL 850324

Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.

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Mizolastine, CAS 108612-45-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 35.00
25 mg	In stock	$ 53.00
50 mg	In stock	$ 68.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 187.00
500 mg	In stock	$ 313.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 99.77%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.
Targets&IC50	H1 receptor:47 nM
Kinase Assay	ssay for cytokines: The cultures for cytokine production are set up at 37 °C as follows: the mixtures of SN-4 and autologous APC (each 1 × 105 cells/well) are cultured for 3 days with 50 μg/mL of Cry j1 in a total volume of 0.2 mL in round-bottomed micro plates; PBMC (2 × 10 5 cells/well) from normal donors are cultured for 24 hours with 10 μg/ml of PHA in a total volume of 0.2 mL in flat-bottomed, 96-well micro plates; and purified T cells (1 × 105 cells/well) from normal donors are cultured in a total volume of 1 ml for 24 hours with anti-CD3 mAb that have been immobilized on flat-bottomed, 24-well plates at a concentration of 5 μg/ml. Cytokines in the culture supernatants are quantitatively assayed by the following commercially available kits: IL-4 and IFN-γ. The sensitivity of the assay is 30 pg/mL for IL-4 and 1 U/mL for IFN-γ.

Synonyms	SL 850324
Molecular Weight	432.49
Formula	C24H25FN6O
CAS No.	108612-45-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (27.75 mM)

References and Literature

1. Brostoff J, et al.Allergy. 1996 May; 51(5):320-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library Anti-Viral Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mizolastine 108612-45-9 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor mast cells SL-850324 second generation antihistamine SL850324 SL 850324 allergic rhinitis inhibit chronic idiopathic urticarial Inhibitor inhibitor

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