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NS-638

Catalog No. T3543 CAS 150493-34-8

Synonyms: NS 638

NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).

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NS-638, CAS 150493-34-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 239.00
50 mg	In stock	$ 385.00
100 mg	In stock	$ 522.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 98.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
Targets&IC50	Ca2+ channel:3.4 μM
In vitro	NS-638 dose-dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons (IC50: 2.3 and 4.3 μM), respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked (IC50: 3.4 μM). At this concentration, no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells (1-30 μM).
In vivo	In the mouse model of middle cerebral artery occlusion, NS-638 administration (50 mg/kg, i.p.) at 1 hour and 6 hours after ischemia, followed by daily dosing for two subsequent days, leads to a 48% decrease in overall infarct volume. However, it fails to demonstrate neuroprotective effects in the gerbil model of bilateral carotid artery occlusion against ischemic neuronal damage.
Cell Research	NS-638 is prepared in 1% DMSO and 1% ethanol. The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].

Synonyms	NS 638
Molecular Weight	325.72
Formula	C15H11ClF3N3
CAS No.	150493-34-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (168.86 mM)

References and Literature

1. Møller, A., Christophersen, P., Drejer, J., Axelsson, O., Peters, D., Jensen, L., & Nielsen, E. (1995). Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res, 17(5), 353-60.

Related compound libraries

This product is contained In the following compound libraries：

Fluorochemical Library Ion Channel Inhibitor Library Preclinical Compound Library Bioactive Compounds Library Max Metabolism Compound Library NO PAINS Compound Library ReFRAME Related Library Neuronal Signaling Compound Library Anti-Hypertension Compound Library Calcium Channel Compound Library

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Keywords

NS-638 150493-34-8 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels Inhibitor inhibit NS638 Ca2+ channels NS 638 inhibitor

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