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NSC348884

Catalog No. T6909 CAS 81624-55-7

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.

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NSC348884, CAS 81624-55-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 56.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 190.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 450.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 77.00

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Purity: 99.91%

Purity: 99.65%

Biological Description

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Description	NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
Targets&IC50	Nucleophosmin:1.7-4.0 μM
In vitro	NSC348884 disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.
In vivo	In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2].

Molecular Weight	636.79
Formula	C38H40N10
CAS No.	81624-55-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (78.52 mM)

References and Literature

1. W Qi,et al. Oncogene. 2008, 27:4210-4220. 2. Patsialou,et al. Breast Cancer Research. 2012, 14:R139. 3. Wang X Y, Wu K H, Pang H L, et al. Study on the Role of Cytc in Response to BmNPV Infection in Silkworm, Bombyx mori (Lepidoptera)[J]. International journal of molecular sciences. 2019, 20(18): 4325.

Citations

1. Wang X Y, Wu K H, Pang H L, et al. Study on the Role of Cytc in Response to BmNPV Infection in Silkworm, Bombyx mori (Lepidoptera). International journal of molecular sciences. 2019, 20(18): 4325.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Apoptosis Compound Library Anti-Colorectal Cancer Compound Library NO PAINS Compound Library Ubiquitination Compound Library Transcription Factor-Targeted Compound Library HIF-1 Signaling Pathway Compound Library Glutamine Metabolism Compound Library Anti-COVID-19 Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NSC348884 81624-55-7 Apoptosis p53 lymphoma cancer inhibit SKOV3 MOSEC/Luc cell LNCaP doxorubicin Inhibitor NSC-348884 ES2 small molecular NSC 348884 inhibitor

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