Shopping Cart
- Remove All
- Your shopping cart is currently empty
ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $162 | In Stock | |
25 mg | $275 | In Stock | |
50 mg | $441 | In Stock | |
100 mg | $649 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist. |
In vitro | In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1]. |
In vivo | ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2]. |
Molecular Weight | 440.46 |
Formula | C24H23F3N4O |
Cas No. | 1807861-48-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (113.52 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.