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ONC212

Catalog No. T7398Cas No. 1807861-48-8

ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.

ONC212

ONC212

Catalog No. T7398Cas No. 1807861-48-8
ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$98In Stock
10 mg$162In Stock
25 mg$275In Stock
50 mg$441In Stock
100 mg$649In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:≥95%
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Product Introduction

Bioactivity
Description
ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.
In vitro
In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1].
In vivo
ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2].
Chemical Properties
Molecular Weight440.46
FormulaC24H23F3N4O
Cas No.1807861-48-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (113.52 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2704 mL11.3518 mL22.7035 mL113.5177 mL
5 mM0.4541 mL2.2704 mL4.5407 mL22.7035 mL
10 mM0.2270 mL1.1352 mL2.2704 mL11.3518 mL
20 mM0.1135 mL0.5676 mL1.1352 mL5.6759 mL
50 mM0.0454 mL0.2270 mL0.4541 mL2.2704 mL
100 mM0.0227 mL0.1135 mL0.2270 mL1.1352 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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