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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $61 | In Stock | |
10 mg | $85 | In Stock | |
50 mg | $207 | In Stock | |
100 mg | $369 | In Stock | |
1 mL x 10 mM (in DMSO) | $68 | In Stock |
Description | Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor. |
In vitro | Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells. [1] |
In vivo | In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis. [1] |
Cell Research | For cancer stem cells, spheres are dissociated and plated under cancer stem cell culture conditions on coated 96-well plates. After 72 h of culture, wells are dosed with the indicated compounds. Seventy-two hours or 24 h after dosing, CellTiter-Glo 2.0 is added to each well, and the luminescence is measured as described by the manufacturer. IC50 values are calculated by fitting a four parameter dose–response curve to normalized data using GraphPad Prism software. For bulk cells, cells are plated at 5,000 cells per well on 96-well plates. Twenty-four hours after plating, cells are treated with the indicated compounds. Viability is determined at 72 h as described above.(Only for Reference) |
Alias | BBI608 |
Molecular Weight | 240.21 |
Formula | C14H8O4 |
Cas No. | 83280-65-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 6.88 mg/mL (28.62 mM) ![]() acetonitrile: 0.799 mg/ml (3.3278 mM) ![]() Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
acetonitrile/DMSO
DMSO
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