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Naproxen sodium

Catalog No. T1582L CAS 26159-34-2

Synonyms: Miranax, Anaprox, RS-3650, Naprelan

Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.

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Naproxen sodium, CAS 26159-34-2

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500 mg	In stock	$ 41.00

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Purity: 100%

Purity: 99.82%

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Chemical Properties

Storage & Solubility Information

Description	Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
Targets&IC50	COX-2:5.2 μM, COX-1:8.7 μM
In vitro	In rat models of carrageenan-induced arthritis and attenuation of pain perception (IC50=27 μM) as well as yeast-induced fever (IC50=40 μM), Naproxen exhibits inhibitory effects. Additionally, in rats, Naproxen suppresses the production of PGE2 (IC50=12.8 μM) and TXB2 (IC50=5.9 μM) triggered by lipopolysaccharides.
In vivo	In HCA-7 colon cancer cells (IC50=1.45 mM), high concentrations of Naproxen induce apoptosis. Within cells, Naproxen inhibits COX-1 (IC50=2.2 μg/mL) and COX-2 (IC50=1.3 μg/mL).
Kinase Assay	COX-1 and COX-2 activities in intact cells: For the determination of COX-1 and COX-2 inhibition, bovine aortic endothelial cells (BAEC) are incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), and cultured J774.2 macrophages are treated with endotoxin at 1 μg/mL for 12 hours to induce COX-2 followed by incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), respectively. Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 minutes at 37 °C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF1α, PGE2, thromboxane B2, or PGF2α for the assessment of IC50 for COX-1 and COX-2.
Cell Research	Cells are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.(Only for Reference)

Synonyms	Miranax, Anaprox, RS-3650, Naprelan
Molecular Weight	252.24
Formula	C14H13NaO3
CAS No.	26159-34-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.55 mg/mL (18.02 mM)

H2O: 198.2 mM

References and Literature

1. Mitchell JA, et al. Proc Natl Acad Sci, 1993, 90(24), 11693-11697. 2. Huntjens DR, et al. Br J Pharmacol, 2006, 148(4), 396-404. 3. Grossman CJ, et al. Inflamm Res, 1995, 44(6), 253-257. 4. Tavolari S, et al. Carcinogenesis, 2008, 29(2), 371-380. 5. Krekels EH, et al. Pharm Res, 2011, 28(7), 1561-1576.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Clinical Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library

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Keywords

Naproxen sodium 26159-34-2 Autophagy Immunology/Inflammation Neuroscience COX inhibit RS 3650 Naproxen Miranax Anaprox RS-3650 Cyclooxygenase RS3650 Inhibitor Naprelan inhibitor

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