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Obtusifolin

Catalog No. T4S0969 CAS 477-85-0

1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone metastasis agent. 3. Obtusifolin has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina, can help prevent vision loss in diabetic patients. 4. Obtusifolin and gluco-Obtusifolin produce significant antinociceptive action in rodent behavioral models of inflammatory/neuropathic pain, and that this activity is associated with modulation of neuroinflammation in spinal cord. 5. Gluco-Obtusifolin and its aglycone may be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by the enhancement of cholinergic signaling.

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Obtusifolin, CAS 477-85-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 293.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 693.00
100 mg	In stock	$ 982.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 100%

Purity: 99.79%

Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Fabaceae > Cassia

Molecular Weight	284.26
Formula	C16H12O5
CAS No.	477-85-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL(80.9 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Hsu Y L , Tsai E M , Hou M F , et al. Obtusifolin Suppresses Phthalate Esters-Induced Breast Cancer Bone Metastasis by Targeting Parathyroid Hormone-Related Protein[J]. Journal of Agricultural & Food Chemistry, 2014, 62(49):11933-40.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Tibetan medicine Compound Library Anti-Gastroenteritis Natural Product Library Transcription Factor-Targeted Compound Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Obtusifolin 477-85-0 NF-Κb oxidation-reduction NF-κB Antioxidant Nuclear factor-κB epithelial Nuclear factor-kappaB Inhibitor inhibit breast cancer mucin esters airway bone phthalate metastasis MUC5AC inhibitor

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