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Oseltamivir phosphate

Catalog No. T1486 CAS 204255-11-8

Synonyms: GS 4104

Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.

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Oseltamivir phosphate Chemical Structure

Oseltamivir phosphate, CAS 204255-11-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.78%

Purity: 99.77%

Purity: 99.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.
In vitro	Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor blocks Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells[2]. Oseltamivir slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
In vivo	Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers)[2]. It is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice[3]. After dosing, the prodrug (Oseltamivir phosphate) is readily absorbed from the gastrointestinal tract and rapidly converted into the active metabolite, OC. In all patient groups, OC has high bioavailability and is systemically distributed to infection sites at concentrations sufficient to inhibit a range of influenza virus neuraminidases[4].
Cell Research	Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.(Only for Reference)

Synonyms	GS 4104
Molecular Weight	410.4
Formula	C16H28N2O4·H3PO4
CAS No.	204255-11-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (24.37 mM)

References and Literature

1. Li W, et al. Antimicrob Agents Chemother. 1998, 42(3):647-53. 2. Haxho F, et al. Breast Cancer (Dove Med Press). 2014, 6:191-203. 3. Leneva IA, et al. Antiviral Res. 2000, 48(2):101-15. 4. Davies BE, et al. J Antimicrob Chemother. 2010, 65 Suppl 2:ii5-ii10. 6. Huang H, et al. Transplacental transfer of Oseltamivir phosphate and its metabolite Oseltamivir carboxylate using the ex vivo human placenta perfusion model in Chinese Hans population. J Matern Fetal Neonatal Med. 2016 Aug 8:1-5. 7. Li P, et al. A Simple and Robust Approach for Evaluation of Antivirals Using a Recombinant Influenza Virus Expressing Gaussia Luciferase. Viruses. 2018 Jun 13;10(6). pii: E325. 8. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643.

Citations

1. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Pediatric Drug Library Anti-Infection Compound Library FDA-Approved Drug Library NO PAINS Compound Library ReFRAME Related Library Orally Active Compound Library Bioactive Compounds Library Max

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Keywords

Oseltamivir phosphate 204255-11-8 Microbiology/Virology Influenza Virus GS4104 Oseltamivir Phosphate inhibit GS 4104 Oseltamivir GS-4104 Inhibitor inhibitor

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