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PF-06305591

PF-06305591 is an effective and selective blocker of voltage-gated sodium channel NaV1.8 (IC50 = 15 nM).

Catalog No. T12424Cas No. 1449473-97-5

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Purity:99.88%

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COA HNMR HPLC

PF-06305591

Catalog No. T12424Cas No. 1449473-97-5

PF-06305591 is an effective and selective blocker of voltage-gated sodium channel NaV1.8 (IC50 = 15 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$97	In Stock
10 mg	$178	In Stock
25 mg	$372	In Stock
50 mg	$556	In Stock
100 mg	$783	In Stock
500 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

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Product Introduction

Bioactivity

Description	PF-06305591 is an effective and selective blocker of voltage-gated sodium channel NaV1.8 (IC50 = 15 nM).
Targets&IC50	Nav1.8:15 nM
In vitro	PF-06305591 shows high NaV selectivity, passive permeability, hERG activity, and in vitro metabolic stability[1].
In vivo	PF-06305591 shows good bioavailability in rats and can be used in studies about the treatment of pain[1].
Alias	PF-6305591

Chemical Properties

Molecular Weight	274.36
Formula	C₁₅H₂₂N₄O
Cas No.	1449473-97-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (164.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6448 mL	18.2242 mL	36.4485 mL	182.2423 mL
5 mM	0.7290 mL	3.6448 mL	7.2897 mL	36.4485 mL
10 mM	0.3645 mL	1.8224 mL	3.6448 mL	18.2242 mL
20 mM	0.1822 mL	0.9112 mL	1.8224 mL	9.1121 mL
50 mM	0.0729 mL	0.3645 mL	0.7290 mL	3.6448 mL
100 mM	0.0364 mL	0.1822 mL	0.3645 mL	1.8224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PF6305591PF 06305591PF-06305591PF06305591PF 6305591