Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 343.00 | |
100 mg | In stock | $ 497.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. |
Targets&IC50 | CK1ε:32 nM, CKIδ:711 nM |
In vitro | PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 (32 nM) has little effect on the circadian clock [1]. |
In vivo | PF-4800567 (100 mg/kg, s.c.) is rapidly absorbed and distributed in plasma and brain of mice [1]. |
Molecular Weight | 359.81 |
Formula | C17H18ClN5O2 |
CAS No. | 1188296-52-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (166.76 mM)
You can also refer to dose conversion for different animals. More
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PF-4800567 1188296-52-7 Metabolism Stem Cells Casein Kinase inhibit PF4800567 PF 4800567 Inhibitor inhibitor