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PF-4800567
🥰Excellent
Catalog No. T5056Cas No. 1188296-52-7
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
PF-4800567
🥰Excellent
Purity: 98.23%
Catalog No. T5056Cas No. 1188296-52-7
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $38 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $137 | In Stock | |
| 50 mg | $206 | In Stock | |
| 100 mg | $298 | In Stock | |
| 200 mg | $433 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $42 | In Stock |
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Purity:98.23%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. |
| Targets&IC50 | CKIδ:711 nM, CK1ε:32 nM |
| In vitro | PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 (32 nM) has little effect on the circadian clock [1]. |
| In vivo | PF-4800567 (100 mg/kg, s.c.) is quickly absorbed and distributed in the plasma and brain of mice [1]. |
| Molecular Weight | 359.81 |
| Formula | C17H18ClN5O2 |
| Cas No. | 1188296-52-7 |
| Smiles | Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1 |
| Relative Density. | 1.52 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (166.76 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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