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PF-9363

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Purity:99.25%

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COA HNMR HPLC

PF-9363

Catalog No. T9167Cas No. 2569009-58-9

PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

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Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$417	In Stock
50 mg	$555	In Stock
100 mg	$773	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description	PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
In vitro	PF-9363 (0~1 μM; 1 day) down-regulates the expression of H3K23Ac biomarker in ZR75-1, T47D and MCF7 cells[1]. PF-9363 downregulates a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. The IC50 values of PF-9363 for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1].
In vivo	PF-9363 exihibits strong anti-tumor activity in patient-derived xenograft models[1].
Alias	CTX-3648

Chemical Properties

Molecular Weight	444.46
Formula	C20H20N4O6S
Cas No.	2569009-58-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (123.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2499 mL	11.2496 mL	22.4992 mL	112.4961 mL
5 mM	0.4500 mL	2.2499 mL	4.4998 mL	22.4992 mL
10 mM	0.2250 mL	1.1250 mL	2.2499 mL	11.2496 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6248 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2499 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc