Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 75.00 | |
5 mg | In stock | $ 185.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 555.00 | |
50 mg | In stock | $ 792.00 | |
100 mg | In stock | $ 1,070.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 275.00 |
Description | Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors. |
In vitro | Pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition at some concentrations. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment. Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity of less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on the expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range [1]. |
In vivo | Pan-RAS-IN-1-treated mice show decreased tumor pERK levels compared with vehicle-treated mice. Pan-RAS-IN-1 administration causes inhibition of tumor growth over 15 days of treatment. A modest increase in cleaved caspase-3 is also observed, showing that pan-RAS-IN-1 has the capacity to induce caspase activation in this model[1]. |
Molecular Weight | 717.65 |
Formula | C36H41Cl2F3N6O2 |
CAS No. | 1835283-94-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (69.67 mM)
You can also refer to dose conversion for different animals. More
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Pan-RAS-IN-1 1835283-94-7 GPCR/G Protein MAPK Ras PanRASIN1 inhibit Pan RAS IN 1 Inhibitor inhibitor