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Perhexiline maleate

Catalog No. T12408   CAS 6724-53-4

Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.

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Perhexiline maleate Chemical Structure
Perhexiline maleate, CAS 6724-53-4
Pack Size Availability Price/USD Quantity
2 mg In stock $ 51.00
5 mg In stock $ 82.00
10 mg In stock $ 124.00
25 mg In stock $ 224.00
50 mg In stock $ 332.00
100 mg In stock $ 497.00
200 mg In stock $ 678.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 99.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.
Targets&IC50 Rat liver CPT 1:148 μM (IC50), Rat heart CPT 1:77 μM (IC50)
In vitro Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells[2].
In vivo The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO.
Molecular Weight 393.56
Formula C23H39NO4
CAS No. 6724-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (69.87 mM)

TargetMolReferences and Literature

1. Kennedy JA, et al. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by Perhexiline and amiodarone. Biochem Pharmacol. 1996 Jul 26;52(2):273-80. 2. Vella S, et al. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA. Sci Rep. 2015 Dec 17;5:18144.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library Anti-Aging Compound Library Reprogramming Compound Library Drug Repurposing Compound Library Approved Drug Library Mitochondria-Targeted Compound Library Cuproptosis Compound Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Perhexiline maleate 6724-53-4 Metabolism Others Mitochondrial Metabolism inhibit Perhexiline Perhexiline Maleate Inhibitor inhibitor

 

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