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Phorbol 12,13-dibutyrate

Catalog No. T16526 CAS 37558-16-0

Synonyms: PDBu, Phorbol dibutyrate

Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.

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Phorbol 12,13-dibutyrate Chemical Structure

Phorbol 12,13-dibutyrate, CAS 37558-16-0

Pack Size	Availability	Price/USD	Quantity
1 mg	4-5 weeks	$ 240.00
10 mg	4-5 weeks	$ 1,440.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
In vitro	Phorbol 12,13-dibutyrate (1 MM) activates PKC. It also inhibited Na/K-ATPase transport activity in OK cells[3].

Synonyms	PDBu, Phorbol dibutyrate
Molecular Weight	504.61
Formula	C28H40O8
CAS No.	37558-16-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (247.72 mM)

References and Literature

1. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25. 2. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62. 3. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

Related Products

Related compounds with same targets

PKC-iota inhibitor 1 Decursin 1,2-Dipalmitoyl-sn-glycerol D-ERYTHRO-SPHINGOSINE PKCiota-IN-2 ɛPKC(85–92),Myristoylated K-252c [Ala107]-MBP (104-118) acetate

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Keywords

Phorbol 12,13-dibutyrate 37558-16-0 Chromatin/Epigenetic Cytoskeletal Signaling PKC Phorbol Phorbol Dibutyrate Phorbol 12,13dibutyrate Phorbol 12,13 dibutyrate PDBu Phorbol dibutyrate inhibitor inhibit

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