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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $139 | In Stock | |
25 mg | $289 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $672 | In Stock | |
1 mL x 10 mM (in DMSO) | $100 | In Stock |
Description | Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling. |
In vitro | Pitstop2 potently and specifically reduced HIV-1 infectivity by >90% in HeLa cells. Preincubation of HeLa cells with Pitstop2 (Pitstops 2) leads to a dose-dependent inhibition of Tf uptake with an IC50 value (12-5 μM). Application of 30 μM Pitstop2 completely blocked Tf endocytosis. Pitstop2-induced block of Tf endocytosis in HeLa cells was completely reversed within 1-3 hr of drug washout. In U2OS cells, the IC50 for Tf uptake is 9.7 μM. Pitstop 2 also causes a potent inhibition of EGF uptake[1]. |
Molecular Weight | 473.36 |
Formula | C20H13BrN2O3S2 |
Cas No. | 1419320-73-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 6.88 mg/mL (14.52 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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