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Pleconaril

Catalog No. T4536   CAS 153168-05-9
Synonyms: VP 63843, Win 63843, Picovir

Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).

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Pleconaril Chemical Structure
Pleconaril, CAS 153168-05-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 73.00
10 mg In stock $ 110.00
25 mg In stock $ 235.00
50 mg In stock $ 391.00
100 mg In stock $ 576.00
200 mg In stock $ 793.00
1 mL * 10 mM (in DMSO) In stock $ 73.00
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Purity: 99.88%
Purity: 99.09%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
Targets&IC50 capsid:50 nM
In vitro Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell.
Synonyms VP 63843, Win 63843, Picovir
Molecular Weight 381.35
Formula C18H18F3N3O3
CAS No. 153168-05-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (131.11 mM), warmed

TargetMolReferences and Literature

1. Benschop KS, et al. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. J Gen Virol. 2015 Mar;96(Pt 3):571-9. 2. Lacroix C, et al. In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Virol J. 2015 Jul 14;12:106.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Viral Compound Library Clinical Compound Library Bioactive Compounds Library Max Anti-Alzheimer's Disease Compound Library Anti-Infection Compound Library Drug Repurposing Compound Library NO PAINS Compound Library Pediatric Drug Library Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pleconaril 153168-05-9 Immunology/Inflammation Microbiology/Virology Antiviral Virus Protease Win-63843 Inhibitor HEVs HEV VP-63843 Enterovirus VP 63843 inhibit Win 63843 Picovir HRV Win63843 HRVs VP63843 Rhinovirus inhibitor

 

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