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Immunology / Inflammation MRP Propafenone

Propafenone

Catalog No. T0866   CAS 54063-53-5
Synonyms: Rythmol, Propafenonum

Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.

Propafenone, CAS 54063-53-5
Pack Size Availability Price/USD Quantity
5 mg In stock 38.00
10 mg In stock 50.00
25 mg In stock 76.00
50 mg In stock 122.00
100 mg In stock 159.00
200 mg In stock 224.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
Targets&IC50 MRP1,   Potassium Channel,   Sodium Channel,  
Synonyms Rythmol , Propafenonum
Purity 99.69%
Molecular Weight 341.44
Formula C21H27NO3
CAS No. 54063-53-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Overington JP, et al. Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Ion Channel Inhibitor Library FDA-approved Drug Library Immunology/Inflammation Compound Library Anti-Cardiovascular Disease Compound Library

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