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Protirelin Acetate(24305-27-9 free base)

Catalog No. T6956L CAS T6956L

Synonyms: Thyroliberin Acetate, TRF Acetate, Synthetic thyrotropin-releasing hormone Acetate, Lopremone Acetate, pGlu-His-Pro-NH2 Acetate, TRH Acetate

Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.

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Protirelin Acetate(24305-27-9 free base) Chemical Structure

Protirelin Acetate(24305-27-9 free base), CAS T6956L

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 62.00
25 mg	In stock	$ 127.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 356.00
200 mg	In stock	$ 515.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 100%

Biological Description

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Description	Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.
In vivo	Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin
Animal Research	Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.

Synonyms	Thyroliberin Acetate, TRF Acetate, Synthetic thyrotropin-releasing hormone Acetate, Lopremone Acetate, pGlu-His-Pro-NH2 Acetate, TRH Acetate
Molecular Weight	422.44
Formula	C18H26N6O6
CAS No.	T6956L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (65.1 mM)

References and Literature

1. Van Sinay E,etal.Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074. 2. Noda Y,etal.Hyperthermia induced by thyrotropin-releasing hormone (TRH, protirelin) in the rat.Kurume Med J. 1979;26(2):107-12.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library FDA-Approved Drug Library NO PAINS Compound Library Human Endogenous Metabolite Compound Library Plus Bioactive Compound Library Approved Drug Library ReFRAME Related Library Endocrinology-Hormone Compound Library RO5 Drug-like Natural Product Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

TR antagonist 1 Resmetirom Liothyronine sodium REVERSE T3 Protirelin PCO371 Sobetirome Protirelin Acetate

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Keywords

Protirelin Acetate(24305-27-9 free base) T6956L Endocrinology/Hormones Thyroid hormone receptor(THR) Protirelin Acetate(24305279 free base) Thyroliberin Acetate TRF Acetate Synthetic thyrotropin-releasing hormone Acetate Lopremone Acetate pGlu-His-Pro-NH2 Acetate TRH Acetate Protirelin Acetate(24305 27 9 free base) inhibitor inhibit

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