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RG2833

Catalog No. T6639 CAS 1215493-56-3

Synonyms: RGFP109

RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

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RG2833, CAS 1215493-56-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 87.00
25 mg	In stock	$ 103.00
50 mg	In stock	$ 122.00
100 mg	In stock	$ 198.00
200 mg	In stock	$ 331.00
500 mg	In stock	$ 559.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.13%

Purity: 99%

Purity: 98.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
Targets&IC50	HDAC1:32 nM(Ki), HDAC3:5 nM(Ki)
In vitro	In unstimulated peripheral blood mononuclear cells, RG2833 upregulates the level of the synaptic mRNA and protein in a dose-dependent manner.
Kinase Assay	Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit.

Synonyms	RGFP109
Molecular Weight	339.43
Formula	C20H25N3O2
CAS No.	1215493-56-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 63 mg/mL (185.6 mM)

Ethanol: 10 mg/mL (29.46 mM)

References and Literature

1. Rai M, et al. PLoS One. 2010, 5(1), e8825. 2. Sandi C, et al. Neurobiol Dis. 2011, 42(3), 496-505. 3. Johnston TH, et al. Parkinsonism Relat Disord. 2013, 19(2), 260-264.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library ReFRAME Related Library Reprogramming Compound Library CNS-Penetrant Compound Library Cancer Cell Differentiation Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Acefylline Tubastatin A Hydrochloride SP-2-225 PRO-HD3 Trichostatin A GK444 BRD73954 HDAC-IN-57

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RG2833 1215493-56-3 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC RGFP-109 Inhibitor RG 2833 RGFP109 inhibit RGFP 109 Histone deacetylases RG-2833 inhibitor

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