Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RTC-5 (TRC-382) (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 723.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | RTC-5 (TRC-382) (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways. |
Targets&IC50 | EGFR: |
In vitro | H1650 lung adenocarcinoma cell growth inhibited by RTC-5 (0-40 μM; 48 hours) (GI50 of 12.6μM). RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1]. |
Synonyms | TRC-382 |
Molecular Weight | 510.96 |
Formula | C24H22ClF3N2O3S |
CAS No. | 1423077-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13.5mg/mL (26.4mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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RTC-5 1423077-49-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR RTC 5 TRC-382 TRC 382 TRC382 RTC5 inhibitor inhibit