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RTC-5
🥰Excellent
Catalog No. T12777Cas No. 1423077-49-9
Alias TRC-382
RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.
RTC-5
🥰Excellent
Purity: 98.14%
Catalog No. T12777Alias TRC-382Cas No. 1423077-49-9
RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $48 | In Stock | |
| 10 mg | $73 | In Stock | |
| 25 mg | $172 | In Stock | |
| 50 mg | $298 | In Stock | |
| 100 mg | $433 | In Stock | |
| 500 mg | $912 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock |
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Purity:98.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways. |
| Targets&IC50 | EGFR: |
| In vitro | H1650 lung adenocarcinoma cell growth inhibited by RTC-5 (0-40 μM; 48 hours) (GI50 of 12.6μM). RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1]. |
| Alias | TRC-382 |
| Molecular Weight | 510.96 |
| Formula | C24H22ClF3N2O3S |
| Cas No. | 1423077-49-9 |
| Smiles | FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12 |
| Relative Density. | 1.357 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (97.86 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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