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Rimeporide hydrochloride

Catalog No. T5333Cas No. 187870-95-7
Alias EMD-87580 hydrochloride

Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of Sodium hydrogen exchange 1 (NHE-1).

Rimeporide hydrochloride

Rimeporide hydrochloride

Purity: 99.82%
Catalog No. T5333Alias EMD-87580 hydrochlorideCas No. 187870-95-7
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of Sodium hydrogen exchange 1 (NHE-1).
Pack SizePriceAvailabilityQuantity
1 mg$83In Stock
5 mg$197In Stock
10 mg$265In Stock
25 mg$437In Stock
50 mg$592In Stock
100 mg$833In Stock
200 mg$1,120In Stock
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Purity:99.82%
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Product Introduction

Bioactivity
Description
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of Sodium hydrogen exchange 1 (NHE-1).
In vitro
Treatment for 24 h with 10 μM phenylephrine significantly increased cell surface area to 129.6 3.1% of control values. The hypertrophic effect of phenylephrine was completely abrogated by 5 μM of EMD87580 [1].
Cell Research
To induce hypertrophy, myocytes were treated for 10 min or 24 h as appropriate and noted under Results with 10 μM phenylephrine in the absence or presence of the following agents: the NHE-1 inhibitor EMD87580 (5 μM) or cariporide (5 μM), the JNK1/2 inhibitor SP600125, the p38 inhibitor SB203580, the ERK1/2 inhibitor PD98059 (all at 10 μM), and the reverse mode Na+-Ca2+ exchange inhibitor KB-R7943 or SN-6 (both at 10 μM). All drugs were added 30 min before the addition of phenylephrine [1].
Animal Research
Two groups were studied. The treatment group (n = 5) received EMD 87580 at a dose of 5 mg/kg IV bolus 5 min before aortic cross-clamping and 10 mol/L EMD 87580 in the cardioplegic solution. The control group (n = 9) received the same volume of saline vehicle. Systemic pretreatment was used to ensure drug availability during the ischemic period prior to CPA. Direct infusion via cardioplegia ensures drug delivery at the time of ischemia (CPA), and it decreases the variability of drug delivery that may occur during the hemodilution with CPB initiation. Incorporation into the cardioplegia also minimizes the potential variable of drug/extracorporeal circuit interactions. Using this dosing regimen, the plasma concentration of EMD 87580 was in the 2,500 to 3,000 ng/mL range at 10 min after CPB. This concentration has been shown to be effective at Na+/H+ exchanger inhibition in vitro [2].
AliasEMD-87580 hydrochloride
Chemical Properties
Molecular Weight369.84
FormulaC11H16ClN3O5S2
Cas No.187870-95-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 18.5 mg/mL (50 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7039 mL13.5194 mL27.0387 mL135.1936 mL
5 mM0.5408 mL2.7039 mL5.4077 mL27.0387 mL
10 mM0.2704 mL1.3519 mL2.7039 mL13.5194 mL
20 mM0.1352 mL0.6760 mL1.3519 mL6.7597 mL
50 mM0.0541 mL0.2704 mL0.5408 mL2.7039 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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