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Roblitinib

Catalog No. T4235   CAS 1708971-55-4
Synonyms: FGF-401

Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. Roblitinib is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.

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Roblitinib Chemical Structure
Roblitinib, CAS 1708971-55-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 53.00
2 mg In stock $ 76.00
5 mg In stock $ 105.00
10 mg In stock $ 172.00
25 mg In stock $ 323.00
50 mg In stock $ 563.00
100 mg In stock $ 791.00
500 mg In stock $ 1,670.00
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Purity: 99%
Purity: 97.36%
Purity: 97.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. Roblitinib is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
Targets&IC50 FGFR4:1.1 nM
In vivo FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II Clinicalal studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma
Synonyms FGF-401
Molecular Weight 506.56
Formula C25H30N8O4
CAS No. 1708971-55-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

TargetMolReferences and Literature

1. WO2015059668A1

TargetMolCitations

1. Tao Z, Cui Y, Xu X, et al. FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma. Proceedings of the National Academy of Sciences. 2022, 119(40): e2208844119.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Angiogenesis related Compound Library Anti-Lung Cancer Compound Library Osteogenesis Compound Library Kinase Inhibitor Library Target-Focused Phenotypic Screening Library

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Keywords

Roblitinib 1708971-55-4 Angiogenesis Tyrosine Kinase/Adaptors FGFR Hep3B Inhibitor inhibit HEPG2 Fibroblast growth factor receptor JHH HUH7 FGF-401 C552A FGF401 JHH7 FGF 401 inhibitor

 

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