Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. Roblitinib is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 53.00 | |
2 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 105.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 323.00 | |
50 mg | In stock | $ 563.00 | |
100 mg | In stock | $ 791.00 | |
500 mg | In stock | $ 1,670.00 |
Description | Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. Roblitinib is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival. |
Targets&IC50 | FGFR4:1.1 nM |
In vivo | FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II Clinicalal studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma |
Synonyms | FGF-401 |
Molecular Weight | 506.56 |
Formula | C25H30N8O4 |
CAS No. | 1708971-55-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. More
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Roblitinib 1708971-55-4 Angiogenesis Tyrosine Kinase/Adaptors FGFR Hep3B Inhibitor inhibit HEPG2 Fibroblast growth factor receptor JHH HUH7 FGF-401 C552A FGF401 JHH7 FGF 401 inhibitor