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S119-8

Catalog No. T12818   CAS 443639-96-1

RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.

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S119-8 Chemical Structure
S119-8, CAS 443639-96-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 64.00
10 mg In stock $ 113.00
25 mg In stock $ 247.00
50 mg In stock $ 455.00
100 mg In stock $ 672.00
500 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 99.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
In vitro RN-18, that antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G.?RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation.?RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
Molecular Weight 344.45
Formula C23H24N2O
CAS No. 443639-96-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (249.72 mM)

TargetMolReferences and Literature

1. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Infection Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Viral Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

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Isoferulic acid Chebulagic acid Filixic acid ABA HA-IN-1 Tetrahydroepiberberine Triazavirin Ermanin Chelidonine

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Keywords

S119-8 443639-96-1 Microbiology/Virology Influenza Virus S-119-8 viruses spectrum S119 8 inhibit Inhibitor influenza S1198 inhibitor

 

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