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S55746
🥰Excellent
Catalog No. T12824LCas No. 1448584-12-0
Alias BLC201
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
S55746
🥰Excellent
Purity: 97.14%
Catalog No. T12824LAlias BLC201Cas No. 1448584-12-0
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 48 € | In Stock | |
| 2 mg | 70 € | In Stock | |
| 5 mg | 104 € | In Stock | |
| 10 mg | 190 € | In Stock | |
| 25 mg | 344 € | In Stock | |
| 50 mg | 549 € | In Stock | |
| 100 mg | 791 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 126 € | In Stock |
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Purity:97.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM). |
| Targets&IC50 | BCL2:1.3 nM (ki), BCL2:3.9 nM (kd) |
| In vitro | S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1]. |
| In vivo | S55746 is a potent and well-tolerated oral BCL-2 inhibitor, effective even at doses up to 300 mg/kg. At doses of 20-100 mg/kg (p.o.), S55746 inhibits xenograft growth in RS4 [1]. |
| Alias | BLC201 |
| Molecular Weight | 710.82 |
| Formula | C43H42N4O6 |
| Cas No. | 1448584-12-0 |
| Smiles | Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 44 mg/mL (61.9 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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