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S55746

Catalog No. T12824L   CAS 1448584-12-0
Synonyms: BLC201

S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).

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S55746 Chemical Structure
S55746, CAS 1448584-12-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
2 mg In stock $ 74.00
5 mg In stock $ 110.00
10 mg In stock $ 200.00
25 mg In stock $ 363.00
50 mg In stock $ 578.00
100 mg In stock $ 833.00
1 mL * 10 mM (in DMSO) In stock $ 133.00
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Purity: 98.99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
Targets&IC50 Bcl-2:1.3 nM (ki), Bcl-2:3.9 nM (kd)
In vitro S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1].
In vivo S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor. S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4 [1].
Synonyms BLC201
Molecular Weight 710.82
Formula C43H42N4O6
CAS No. 1448584-12-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (61.9 mM), sonification is recommended.

TargetMolReferences and Literature

1. Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Mitochondria-Targeted Compound Library Clinical Compound Library Bioactive Compound Library Inhibitor Library Apoptosis Compound Library

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Keywords

S55746 1448584-12-0 Apoptosis BCL inhibit BLC201 S-55746 BCL-201 Inhibitor S 55746 Bcl-2 Family BCL 201 BLC-201 BCL201 BLC 201 inhibitor

 

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