Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 110.00 | |
10 mg | In stock | $ 200.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 833.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM). |
Targets&IC50 | Bcl-2:1.3 nM (ki), Bcl-2:3.9 nM (kd) |
In vitro | S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1]. |
In vivo | S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor. S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4 [1]. |
Synonyms | BLC201 |
Molecular Weight | 710.82 |
Formula | C43H42N4O6 |
CAS No. | 1448584-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44 mg/mL (61.9 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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