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SAG hydrochloride (912545-86-9(free base))

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Purity:99.19%

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COA HNMR HPLC

SAG hydrochloride (912545-86-9(free base))

Catalog No. T4211Cas No. 2095432-58-7

SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.

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Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$289	In Stock
50 mg	$396	In Stock
100 mg	$593	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Product Introduction

Bioactivity

Description	SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
In vitro	SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
In vivo	In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
Animal Research	Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference)
Alias	Smoothened Agonist HCl

Chemical Properties

Molecular Weight	526.52
Formula	C28H29Cl2N3OS
Cas No.	2095432-58-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 38 mg/mL (72.2 mM)

DMSO: 66 mg/mL (125.4 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8993 mL	9.4963 mL	18.9926 mL	94.9632 mL
5 mM	0.3799 mL	1.8993 mL	3.7985 mL	18.9926 mL
10 mM	0.1899 mL	0.9496 mL	1.8993 mL	9.4963 mL
20 mM	0.0950 mL	0.4748 mL	0.9496 mL	4.7482 mL
50 mM	0.0380 mL	0.1899 mL	0.3799 mL	1.8993 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0190 mL	0.0950 mL	0.1899 mL	0.9496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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