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SC-514

Catalog No. T2118Cas No. 354812-17-2
Alias GK 01140

SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.

SC-514

SC-514

Purity: 100%
Catalog No. T2118Alias GK 01140Cas No. 354812-17-2
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$48In Stock
25 mg$79In Stock
50 mg$116In Stock
100 mg$178In Stock
500 mg$453In Stock
1 mL x 10 mM (in DMSO)$31In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Targets&IC50
IKK2:11.2±4.7 μM
In vitro
In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg).
In vivo
In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM).
AliasGK 01140
Chemical Properties
Molecular Weight224.3
FormulaC9H8N2OS2
Cas No.354812-17-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (178.33 mM), Sonication is recommended.
Ethanol: 2.2 mg/mL (10 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.4583 mL22.2916 mL44.5831 mL222.9157 mL
5 mM0.8917 mL4.4583 mL8.9166 mL44.5831 mL
10 mM0.4458 mL2.2292 mL4.4583 mL22.2916 mL
DMSO
1mg5mg10mg50mg
20 mM0.2229 mL1.1146 mL2.2292 mL11.1458 mL
50 mM0.0892 mL0.4458 mL0.8917 mL4.4583 mL
100 mM0.0446 mL0.2229 mL0.4458 mL2.2292 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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