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SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $30 | In Stock | |
10 mg | $48 | In Stock | |
25 mg | $79 | In Stock | |
50 mg | $116 | In Stock | |
100 mg | $178 | In Stock | |
500 mg | $453 | In Stock | |
1 mL x 10 mM (in DMSO) | $31 | In Stock |
Description | SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
Targets&IC50 | IKK2:11.2±4.7 μM |
In vitro | In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg). |
In vivo | In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM). |
Alias | GK 01140 |
Molecular Weight | 224.3 |
Formula | C9H8N2OS2 |
Cas No. | 354812-17-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (178.33 mM), Sonication is recommended. Ethanol: 2.2 mg/mL (10 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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